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Randall VA, Jenner TJ, Hibberts NA, De Oliveira IO, Vafaee T

The cytotoxicity that results from prevention of catabolism of adenosine or deoxyadenosine is thought to be due to elevated intracellular levels of dATP, which can block DNA synthesis through inhibition of ribonucleotide reductase

The model provides an alternative method of investigating and quantifying redox cycling induced oxidative stress, circumventing the experimental difficulties of measuring and tracking radical species

They found that the E119V + I222L mutant had a 1571-fold higher resistance to oseltamivir than the wild-type, while the E119 V mutation only induced moderate resistance (197-fold) and the I222L mutation only induced mild resistance (9-fold) [51]