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These interactions cause potentiation of L-type Ca 2+ channel activity, enhanced [Ca 2+ ] i , and vasoconstriction (Figure 9)

The histological and ultrastructural findings are identical to those of the CaLS, and so some authors propose to include freckles and CaLS in the same diagnostic criterion.41 We also support this proposal, particularly if we remember that Legius syndrome meets 2 criteria in 48% of cases and presence of both criteria does not increase the specificity of diagnosis.24 Freckles can appear in other genetic diseases included in the differential diagnosis (Table 2), particularly in cases in which they coexist with CaLS

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Here are six ways glutathione can benefit liver health and boost overall well-being: Antioxidant Protection and Detoxification Glutathione is critical for liver detoxification, neutralizing free radicals, and reducing oxidative damage, which is especially beneficial in high-stress conditions like NAFLD