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The TNF antagonist etanercept can significantly enhance the killing effect of the ferroptosis inducer imidazole ketone erastin (IKE) on RA-FLSs, and the combination of the two restores synovial homeostasis by promoting FAP + fibroblasts ferroptosis and reducing the number of FAP + fibroblasts

Phagocytic cells, including neutrophils, monocytes, and macrophages, generate significant amounts of O 2 and NO to combat foreign invaders

Additionally, it is involved in the regulation of learning and memory and provides persistent synaptic strengthening, termed neural long-term potentiation [2,3]

However, some research studies suggest that the use of antioxidants, such as resveratrol, may constitute a therapeutic alternative [17]