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Ethics statement The animal study was approved by Sichuan Academy of Traditional Chinese Medicine

The pathological changes of articular cartilage degradation and synovial hyperplasia were evaluated after receiving continuous GYY4137 intervention for two months (Fig

Normal, healthy adults are generally in nitrogen balance, with intake and excretion being very well matched

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Subsequent vasoconstriction and inflammation ensue, leading to vessel wall remodeling and, finally, to the formation of atherosclerotic lesions as the hallmark of advanced disease