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The FOXO4p53 axis in senescence p53 is a major tumour suppressor and master regulator of cellular stress responses: DNA damage, oxidative stress, oncogene activation

How Long Does Each Take to Work

GLP-1 receptor agonists stimulate glucose-dependent insulin secretion and suppress appetite, whilst metformin reduces hepatic glucose production and enhances insulin sensitivity

Side effects are rare but may include mild pain at the injection site or allergic reactions in some individuals

GH-IGF1 axis dysregulation enhances the synergistic effect of the promotion of uncontrolled cell proliferation, cell migration and invasion, thus promoting cancer initiation and metastasis (Dehkhoda et al., 2018)