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For instance, omega-3 PUFA deficiency in depression diminishes anti-inflammatory eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), while elevating pro-inflammatory arachidonic acid (AA) metabolites (203205)

It often signals that additional metabolic bottlenecks exist beyond AMPK suppression and NNMT overactivity

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doi:10.3389/fnut.2021.612068 36

The glutathione system and the related thiol network in Caenorhabditis elegans