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2009, 532640-7 pages, 2009

Methodologically rigorous studies that couple pathway inhibition to predefined immune and clinical endpoints, deploy standardized biospecimen workflows and use harmonized safety reporting are required to determine whether neurotrophin-targeted strategies can remodel the osteosarcoma microenvironment toward durable immune control

Reduced vascular endothelial cells (ECs) survival and diminished microvascular density can lead to regional hypoperfusion and potentially precipitate cerebrovascular ischemia

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At the low research doses described in the literature, no serious adverse events have been systematically documented