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Taking them together is usually safe

Negi G, Kumar A, Kaundal RK, Gulati A, Sharma SS (2010) Functional and biochemical evidence indicating beneficial effect of melatonin and nicotinamide alone and in combination in experimental diabetic neuropathy

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Key risk factors of vitamin B12 deficiency include: Decreased ability to absorb vitamins as a result of low hydrochloric acid secretion Certain medications Gastrointestinal disease and surgeries Vegans are also at a higher risk of vitamin B12 deficiency Can You Have Too Much Vitamin B12