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During the initial menopausal transition period, the follicle numbers declines and it becomes critical

Delta SleepInducing Peptide (DSIP) directly targets hypothalamic sleep centers, increasing deltawave activity, shortening sleep latency, and modulating nighttime cortisol spikes

10.1128/jb.179.3.880-888.1997

In 2010, a double-blind, randomized, and placebo-controlled clinical trial sought to further investigate SAM in the treatment of depression, but reported no improvements over placebo 15

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