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Curettage & electrodesiccation: Shave or scrape the lesion and apply cautery

This results from a tyramine-induced depletion of norepinephrine normally present in the readily releasable vesicle pool, and replacement of vesicular norepinephrine with tyramine (which functions as a false- or pseudo- neurotransmitter), which when released has no effect on postsynaptic adrenergic receptors (Figure 1)

10.3390/ph17040511 9 BehnkeM.HolickC

However, the mechanism by which truncated Syn variants sequester cellular proteins and damaged organelles to drive LB nucleation remains poorly understood

doi: 10.1083/jcb.201605110 9 ShenQLiangMYangFDengYZNaqviNI