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Additionally, Lambert and Elias (2010) observed that treatment of mice with high oral doses of EGCG resulted in dose-dependent hepatotoxicity, manifested as increased hepatic lipid peroxidation, expression of hepatic metallothionein I/II, and elevated hepatic levels of H2A.X [177]

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10.1111/j.1600-0838.2009.00895.x 153

Leptin is another key hormonal metabolic regulator that is perturbed in obesity

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