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1-(3-dimethylaminopropyl)-3-ethylcarbodiimide (EDC)/N-hydroxy succinimide (NHS) chemistry has been employed to couple these carboxyl groups from heparin with star-shaped PEG end-functionalized amine groups to fabricate hydrogels designed for delivering BMP-2 and VEGF [183]

TB-500 and BPC-157 have relatively favorable safety profiles based on available research and user reports, but they are not risk-free

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