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Fourth, therapeutic heterogeneity: Zhang et al., 2021a demonstrated that baseline gut microbiota diversity critically determines efficacy, with lower diversity correlating with superior outcomes

The occurrence of PSC after colectomy in some patients with UC argues against the possibility that UC is involved in the development of PSC, although triggering of an irrevocable autoimmune process by UC resulting in PSC cannot be excluded

1.14 Levothyroxine and pharmacokinetics Levothyroxine (T4) is an artificial form of thyroxine, the bodys natural thyroid hormone, and has been the mainstay of hypothyroidism treatment since the 1980s