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Computational optimization of each tautomers conformational landscape using CENSO and ORCA programs 50,51 with the def2-mSVP basis set, an efficient method for geometry optimization, revealed that the E isomer predominates in all media over the Z isomer

In contrast, blood glucose level of 54 mg/dL or less occurred in 6% of patients receiving the 14 mg tablets, 3% of patients receiving placebo, and 0% of patients receiving the 7 mg tablets

Animal studies show no toxicity even at doses 1,000 higher than typical use, but that doesn't mean high doses are risk-free in humans (Sikiric et al., 2014)