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10.1016/j.freeradbiomed.2018.09.033 127 MclachlanD

it induces mitochondrial dysfunction in cholestasis and in ischemia/reperfusion injury

In support of this hypothesis, it has been reported that genistein enhanced the activity of neuronal nitric oxide synthases (Miao et al., 2018), which promoted NO synthesis from l-arginine substrate

For example, curcumin has been evaluated in Phase II clinical studies in pancreatic cancer and colorectal cancer patients, where oral doses up to 8 g/day demonstrated acceptable safety but limited systemic exposure, highlighting pharmacokinetic challenges

It is suggestive for clinical practice although further validation of the effectiveness and OIPN of topical administration is required