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A 2025 systematic review published in the HSS Journal examined 36 studies spanning from 1993 to 2024

Additional Growth Factors Modulated EGF (Epidermal): Promotes epithelial cell proliferation and wound re-epithelialization FGF (Fibroblast): Stimulates fibroblast activity and extracellular matrix production TGF- (Transforming): Regulates scarring and tissue remodeling NGF (Nerve): May contribute to BPC-157's neuroprotective effects Growth Factor Coordination These growth factors work synergistically: VEGF brings blood supply (oxygen, nutrients, repair cells) EGF regenerates epithelial surfaces FGF stimulates connective tissue repair TGF- orchestrates the remodeling phase Receptor Interactions BPC-157's mechanism may involve growth factor receptor modulation, though the exact receptors remain under investigation

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