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The extract significantly decreased both the production of reactive oxygen species (ROS) and the secretions of pro-inflammatory cytokines

Li Y, Sabari BR, Panchenko T, Wen H, Zhao D, Guan H, et al

[DOI] [PubMed] [Google Scholar] 119.Rees DC et al

In a mouse model with I/R injury, the combination of cyclosporine A (CsA) and DFX synergistically inhibits I/R-induced iron overload, lipid peroxidation, and cardiomyocyte ferroptosis, reducing infarct size and improving poor cardiac remodeling after I/R injury

[49] Post-marketing worldwide reports in patients receiving oral ketoconazole have included rare cases of paresthesias, and signs of increased intracranial pressure including bulging fontanelles and papilledema