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421,459,460 The thalamus plays a pivotal role in modulating and processing somatosensory inputs before they reach the cerebral cortex and may serve as a central biomarker for neuropathic pain in diabetes mellitus

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XR: 30 to 60 min Among the faster-acting options across both formulations Faster onset Vyvanse Approximately 60 to 120 minutes Slowest onset due to prodrug conversion process in the body Slower onset Ritalin IR: 20 to 30 min

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This was followed by vortex mixing for ~1 min before centrifuging samples at 10,000 relative centrifugal force (RCF) for 20 min at 4C