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La influencia de estos dos parametros en el proceso de retencin es algo muy complejo ya que la variacin de la composicin de la fase mvil (tipo de modificador organico, tipo de buffer y fuerza ionica) induce a una variacin del grado de ionizacin de las molculas (Heinisch y Rocca 2004)

doi: 10.3389/fimmu.2018.00406 151 QiuD.LiG.HuX.WangL.DongY

Journal of Basic and Clinical Physiology and Pharmacology, 31(4), 20190206

Brusatol extracted from a family of natural products known as quassinoids inhibited Nrf2-related cell cycle transition from G2 to M phase, which depends on cyclin B-cyclin-dependent kinase 1 (CDK1) complex (43)