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In other words, cancer cell organotropism is a determination of transformed cells possessing a certain level of metabolic plasticity on whether or not to be ready for colonization in response to the redox levels of the organ microenvironment

Phase I biotransformation seems to be enzymes that catalyzes oxidation, reduction or hydrolyze reactions, it usually converts substrates to more polar forms by introducing or unmasking a functional group (e.g., OH, NH2, or SH)

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Jinhua Xu, [email protected] These authors have contributed equally to this work This article was submitted to Autoimmune and Autoinflammatory Disorders, a section of the journal Frontiers in Immunology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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