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N Engl J Med (2018) 379(12):115060

We also administered sulfasalazine daily from day 30, when TLS were already established, to day 45 post-IRI to assess whether it could revert established TLS (a treatment model

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221 Accordingly, BRAF, ARID1A, RNF43, and KM2B with higher mutation frequencies can be used to predict the prognosis and distinguish MSI from MSS tumours, and they provide guiding significance for the clinical effect of immunotherapy in MSI CRC