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Among patients with IIM, which include polymyositis, dermatomyositis, and antisynthetase syndrome, the prevalence of ILD varies from 36-45%, however, the rates can reach 80% in patients with specific antisynthetase antibodies (Hallowell and Paik, 2021

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Microbiota depletion in mice induces a reduced number of aged neutrophils (CD62L , CXCR4 + ) in the blood, and exhibit significant reductions in neutrophil adhesion/Mac-1 activation compared to untreated mice, leading to a retention of neutrophils in the circulation (77)

A plausible interpretation of the results is that AtGrxS15 was able to react with GSSG and that glutathionylated AtGrxS15 subsequently transferred its glutathione moiety to reduced roGFP2
