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Here the authors report a phase I clinical trial assessing the safety of clinically formulated TS in mesothelioma patients, and identify SLC7A11 as a potential mediator of TS resistance in pre-clinical models.

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By integrating findings from experimental and limited clinical studies, it aims to provide a rational scientific framework to inform future investigation and development of ginsenoside-based strategies for depression, while emphasizing the need for further rigorous clinical validation.

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