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There are multiple locations for sirtuins in somatic cells

Aerobic exercise, such as running, cycling, or other forms of sustained cardiovascular activity, has been shown to promote neurogenesis in the hippocampus

Schott, M

Obesity 31 , 21712177 (2023)

Nucleic Acids Res 44:D46370 Sullivan MR, Danai LV, Lewis CA, Chan SH, Gui DY, Kunchok T, Dennstedt EA, Vander Heiden MG, Muir A (2019) Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability
