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Author Contributions Conceptualization, Q.T
Highlighting the key role testosterone plays as a primary anabolic hormone in muscle adaptation following exercise training, through its interaction with anabolic signaling pathways and other hormones via the androgen receptor (AR), this review also describes the potential importance of fluctuations in other hormones such as GH and IGF-1 in concert with dietary amino acid availability
Apelin enhances mitochondrial biogenesis via activation of AMPK, which upregulates PGC1, NRF1, and TFAM, thereby improving oxidative capacity in insulin-resistant skeletal muscle [42,43]
Nrf2 is well known for mediating the expression of antioxidant and detoxifying proteins in response to oxidative and electrophilic stress (reviewed in [162, 163])
Collagen Reverses skin aging and visibly removes wrinkles, fine lines and other unsightly signs of skin aging
