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demonstrated that robustaflavone, isolated from Selaginella trichoclada, triggered iron-dependent cell death in breast cancer cells by enhancing the expression of voltage-dependent anion channel 2 (VDAC2) and downregulating Nedd4 E3 ubiquitin ligase, resulting in the generation of lipid peroxidation and ROS (Xie et al., 2021)

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And since both are prone to obesity-related dysfunction, this suggests a common pathway leading to the persistent disease progression through visceral fat

J Biol Chem 286(10):80758084

10.1016/j.devcel.2010.03.008 Wang HV, Chang LW, Brixius K, Wickstrom SA, Montanez E, Thievessen I, Schwander M, Muller U, Bloch W, Mayer U, Fassler R: Integrin-linked kinase stabilizes myotendinous junctions and protects muscle from stress-induced damage