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Introduction Our group was the first to describe in humans the existence of an intrinsichypothalamic-somatotrophic rhythm, sexually dimorphic, that conditions the secretion of growth hormone (GH) ( We currently know that GH is a pleiotropic hormone that, in addition to its metabolic and growth effects, has very important positive effects on practically all organs and tissues ( GH expression has been shown to exist at many extra-pituitary sites, including the nervous system, reproductive system, immune system, cardiovascular system, muscle tissue, dermal tissue, skeletal tissue, and even in the eyes ( It seems logical, then, that both the knowledge of the multiple functions that GH plays in the body and the peripheral expression of the hormone have increased the knowledge of the complexity of GH regulation, far beyond the classical concept ( Ghrelin In 1990 it was published that a synthetic hexapeptide called GH-releasing peptide (GHRP) could act as a potent GH secretagogue in normal humans ( Figure 1

doi:10.1002/lary.23790 Reitzen SD, Babb JS, Lalwani AK

TB-500 enhances MMP-2 expression to facilitate cellular migration through provisional matrix while stimulating synthesis of ECM components including collagen types I and III, fibronectin, and hyaluronic acid essential for tissue reconstruction