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Jimbo H, Nagai H, Fujiwara S, Shimoura N, Nishigori C

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37 Macrophages in IUA may adopt a mixed M1/M2 phenotype, retaining pro-inflammatory functions while simultaneously secreting profibrotic factors, which drive fibrosis

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A typical IgG1 antibody has roughly 90 lysine residues, of which approximately 30 can be modified under forcing conditions ( Random conjugation utilizing lysine generates a heterogeneous mixture of conjugate species (11)

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