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Yu J, Chen X, Wang F

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PMC 5171650

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It is worth mentioning the role of hsa-miR-155 in orchestrating signaling molecule expressions to control the viral-induced immune response, namely suppressor of cytokine signaling 1 (SOCS1) [86] , together with viral transcriptional modulators such as Jumonji and AT-Rich interaction domain-containing 2 (Jarid2) [87], proto-oncoprotein1 of the Ets family of transcription factors (Ets1) [88], and FOS Like 2, AP-1 transcription factor subunit (Fosl2) [89], repress T-regulatory cells (Tregs) as well as promote vascular endothelial growth factor (VEGF)-independent angiogenesis [90], leading to more systemic/neuro-inflammation and hence neuro-affection

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Thus, selectively removing senescent cells in chondrocytes is crucial to assure the quality of cells for ACI

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doi: 10.1038/s41380-023-02084-1

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