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Large IV or oral doses of ascorbic acid have caused hemolytic anemia in some patients with G6PD deficiency (glucose-6-phosphate dehydrogenase deficiency)

Illness, certain medications, and exposure to environmental pollutants can contribute to increased free radical production

Rotate by day, evening or treatment session

Antidepressants with high risk of liver injury, such as iproniazid, phenelzine, imipramine, amitriptyline, duloxetine, bupropion, or agomelatine should be avoided 4,180

That potentially, ingredients that could help clear out, or keep clear, the liver so that it has ROOM to do its job, would then mean it will do a better job