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Internal Support (IV Therapy + Supplements) Glutathione IV drips: 1-2x weekly initially, then maintenance Oral glutathione: 500mg daily between IV sessions Vitamin C: 1000mg daily (enhances glutathione effectiveness) Vitamin E: 400 IU daily (synergistic with glutathione) Omega-3s: Reduce inflammation, support skin barrier 2

doi: 10.1001/archinte.167.10.1050 10

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P53 phosphorylation at Ser15 enhances the affinity of both FOXO4 and FOXO4-DRI for p53 TAD2 explaining the preferential engagement of FOXO4-DRI with the hyperphosphorylated p53 characteristic of senescent cells

Available treatments such as levodopa, dopamine agonists and monoamine oxidase B inhibitors offer only symptomatic relief however, they do not treat the underlying neurodegeneration, emphasising the need for neuroprotective management