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Abbreviations NSCLC: Non-small cell lung cancer ICB: Immune checkpoint blockage PFS: Progression free survival OS: Overall survival RR: Response rate PD-L1: Programmed cell death ligand 1 TME: Tumor microenvironment ECM: Extracellular matrix TIB: Tumor infiltrating B cells MPR: Major pathological response NMPR: Non-major pathological response pCR: Pathological complete response FFPE: Formalin-fixed paraffin-embedded ST: Spatial transcriptome UMI: Unique molecular identifiers mIHC: Multiplex immunohistochemistry IHC: Immunohistochemistry TN: Treatment nave PT: Post treatment CT: Computed tomography RCTD: Residual convolutional neural network with the transformer decoder H&E: Hematoxylineosin TLS: Tertiary lymphoid structures CNV: Copy number variations TKI: Tyrosine kinase inhibitors t-SNE: T-distributed stochastic neighbor embedding DEGs: Differentially expressed genes TCR: T cell receptor BCR: B cell receptor References Siegel RL, Giaquinto AN, Jemal A

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