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Moreover, despite the relief opioid drugs can provide for acute clinical and experimental pain (Wanigasekera et al., 2012), psychosocial stress (Bershad et al., 2015, 2018), certain depressive symptoms (Pecia et al., 2018), and feelings of breathlessness (Hayen et al., 2017), opioid blockade does not consistently increase the aversiveness of experimental pain (Anderson et al., 2002

They rely on consistent blood flow, stable glucose handling, healthy mitochondria, and intact myelin

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This is the kind of structured, root-cause approach that Meto's Hormonal & PMOS Management programme is built around physician-led care that uses lab data and symptom tracking to personalise treatment rather than applying a generic protocol