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*Correspondence: Mark O

& Le Cao, K

4.4 Practical considerations in pharmacokinetics and administration routes The synovial cavity, as a natural enclosed space, provides an ideal window for local drug delivery, allowing drugs to act on the lesion site at high concentrations while minimizing systemic exposure and associated potential risks (Yu et al., 2024

M.CasagrandeV.CirioloM

In addition, interactions between T cells and macrophages can influence macrophage activation and may be associated with changes in iNOS expression and inflammatory responses in the vascular wall, thereby contributing to the immunopathogenesis of vasculitis (103)