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This triple-agonist approach, targeting GLP-1, GIP, and glucagon receptors, produced the most dramatic weight loss results seen in any Phase 2 obesity trial

For fatty liver disease itself , NICE guideline NG49 recommends risk stratification in primary care using the FIB-4 score initially, followed by the Enhanced Liver Fibrosis (ELF) test if indicated, to identify patients at higher risk of advanced fibrosis who may require specialist referral

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Combining too many interventions simultaneously makes it impossible to identify what works