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In addition, a known factor in pharmacology, such an excessive amount of folate can actually compete with and block the binding of all folate to natural receptors, resulting in down regulation

It should be noted that the accumulation of GSSG affects the glutathionylation of mitochondrial proteins, thus changing their functioning
Wang S et al., 2024

Wilmer MJ, Ng CP, Lanz HL, Vulto P, Suter-Dick L, Masereeuw R (2016) Kidney-on-a-chip technology for drug-induced nephrotoxicity screening
