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Overall, patient populations studied in IKEMA and CANDOR were quite similar, with a median of 2 prior treatment lines and similar refractoriness to lenalidomide (33 vs

Similarly, BEYOND (a trial that aimed to demonstrate superiority of double-dose interferon beta-1b over the standard dose of 250 mcg and over glatiramer acetate 20 mg daily) did not demonstrate meaningful differences between interferon beta-1b and glatiramer acetate in respect to the primary outcome of the study (relapse risk) (79)

Most manufacturers and regulatory guidelines recommend discarding opened vials after 28 days, regardless of how much solution remains

Diabetes Research and Clinical Practice, 206, 110764
& Coup, P
