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This is now a common theme underlying insulin resistance in other insulin-sensitive tissues such as skeletal muscle

Gojda, J., Strakov, R., Plhalov, A., Tma, P., Potokov, J., Polk, J., et al

Macrophages are known to be a diverse group of tissue-inhabiting professional phagocytes that evolved from THP-1 monocytes (human leukemia monocytic cell line), activated into two main polarization states, resulting in opposite phenotypic forms as the classically activated pro-inflammatory macrophages type 1 (M1) and alternatively activated anti-inflammatory macrophages type 2 (M2) cells

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