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Overproduction of ROS can activate NLR family pyrin domain containing 3 (NLRP3), leading to the formation of inflammasome, maturation of caspase1, and activation of GSDMD, which creates pore structures to mediate inflammation [154]

Examples of such DRs include FasR, TNFR1, LARD (DR3), TRAIL-R1 (DR4), TRAIL-R2 (DR5), and pattern recognition receptors (PRRs) like Toll-like receptors (TLRs) [46, 47]

This is what may lead to cognitive conditions like dementia

PMID: 152 HuangLZhuJWuGXiongWFengJYanCet al

Concluding Thoughts: To survive a motion to dismiss in the plaintiffs needed to support their complaint with detailed benchmarks and specific comparisons demonstrating that ESI was an imprudent choice and also give concrete examples or circumstantial evidence to show that a prudent fiduciary in similar circumstances would have acted differently