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Bioinformatics Prediction Analysis In Silico Functional Prediction Tools Functional predictions were established from sequence homology based on different in silico programs, namely, Mutation Taster ( SIFT (Sorting Intolerant From Tolerant) ( and PolyPhen-2 (Polymorphism Phenotyping v2) ( Both of the SIFT and PolyPhen-2 tools report results in terms of pathogenic scores as benign, tolerated, or deleterious, whereas Mutation Taster scores classified the detected variants to be disease causing or neutral

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