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These chemical mediators can affect multiple organ systems including the respiratory, circulatory, integumentary, digestive, muscular and nervous system

629 As the task of producing large amounts of mucin is challenging to the goblet cells, a controlled unfolded protein response and endoplasmic reticulum (ER) expansion are required to prevent the accumulation of ER stress

Inhibiting MTR could potentially serve as a viable alternative for cancer treatment, prompting a reassessment of drug development efforts
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