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Blood 90:75a, 1997
Tumor-induced glutamine competition promotes glutamate secretion to modulate immune responses Cancer cells strengthen their resistance to tumor-infiltrating lymphocytes (TILs) partly through the metabolites released into the TME, contributing to its hostility
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It also modulates the ERK, JNK, and p38 MAPK signaling cascades, reducing the expression of inflammatory mediators and adhesion molecules (Ling et al
A relative decrease in aconitase activity in the autism cerebellum is an important new finding, suggesting a functional consequence of oxidative stress in this region
