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In addition, mitochondrial dysfunction in stromal cells is the key causal factor triggering fibrosis-induced ovarian decline, and metformins reversal of ovarian fibrosis converges on related mitochondrial metabolic pathways that are upstream of oxidative stress and inflammation (Umehara et al., 2022)
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An important protective role of NRF2 against EtOH-induced oxidative stress and lipotoxicity has been established in in vivo and in vitro studies 47

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doi: 10.1080/17582024.2025.2488235, 29

Cellular turnover takes time
