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GH and IGF System Growth hormone (GH) and the insulin-like growth factor (IGF) system consists of several components: GH, and receptor (GHR), IGF1, IGF2, Insulin-like growth factor 1 receptor (IGF1R), Insulin Like Growth Factor 2 Receptor (IGF2R), IGF binding proteins (IGFBPs), and related proteases which interact with each other and regulate several metabolic processes and body growth ( GH, also known as somatotropin, is produced in the anterior pituitary under the control of growth hormone releasing hormone (GHRH) which induces its synthesis and release ( The bioavailability of both IGF1 and IGF2 is controlled by a superfamily of six IGFBPs (IGFBP 1-6) characterized by a higher affinity for IGFs than IGF receptors ( The GH and IGF system have growth-promoting actions regulating cell proliferation, differentiation, apoptosis and angiogenesis ( MicroRNAs and Long Non-Coding RNAs Are Epigenetic Regulators of Gene Expression MicroRNAs (miRNAs) are a family of small non-coding RNAs (1925 nucleotides -nts) that can regulate a plethora of biological processes via the modulation of the expression of target genes at the post- transcriptional level ( MiRNAs act in a very specific, context-dependent manner, and may have a dual role both as onco-miR and tumor-suppressor miR ( Long non-coding RNAs (lncRNAs) are non-protein coding transcripts with a minimal length of 200 nts, that are important emerging gene expression regulators