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While nuclear factor erythroid 2-related factor 2 and antioxidant enzymes such as heme oxygenase-1, are activated during periods of hypoxic stress to compensate for mitochondrial dysfunction, once a critical threshold of reduced ATP production is reached, ion homeostasis becomes compromised (125)

2004;378(Pt 2):373382

Int J Endocrinol 2012(1):561018 Van Der Fits L, Mourits S, Voerman JS, Kant M, Boon L, Laman JD, Cornelissen F, Mus A-M, Florencia E, Prens EP (2009) Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23/IL-17 axis

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Genetic risk factors associated with NAFLD