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The trial protocol was approved by the Madrid Region Clinical Research Ethics Committee ( Comit tico de Investigacin Clnica Regional de la Comunidad de Madrid ) on February 8 th 2011, and has been registered with ClinicalTrials.gov number NCT 01476007, and under EUDRACT number 2010-024129-20 [Oral Versus Intramuscular Cobalamin to treat Cobalamin Deficiency: Noninferiority randomised controlled trial, pragmatic and multi-center in the primary healthcare setting (OB12 project)]

Researchers appreciate the easier handling of capsules over powder form, reducing measurement errors and contamination risks in the lab

Cardiovascular Health Improvements: The reduction in visceral adipose tissue and improvements in lipid profiles observed with 5-amino-1MQ treatment suggest potential cardiovascular benefits