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The hypoxia alleviation via O2 production, the redox balance disruption via glutathione consumption and the reactive oxygen species generation, together would down-regulate the expression of O6-methylguanine-DNA methyltransferase under TMZ medication, which is considered as the key to drug resistance

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Type 1 diabetes mellitus (T1DM) is a significant global health concern, adversely affecting various metabolic pathways and organ systems, including male reproductive health