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PubMed, Brouwer, I

However, there is a small subset of patients that does not obey this pattern, displaying median expression of NRF2 and low expression of KEAP1 red dots (NRF2-KEAP1 alteration) indicating a higher activity of the transcription factor in those tumors

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Thus, increased IIS with down-regulated nuclear FoxO levels impairs adequate elimination of ROS, a critical mechanism involved in the promotion of acne, T2D and cancer

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