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What stood out: CagriSema achieved 23.0% weight loss at 84 weeks (efficacy estimand) Tirzepatide achieved 25.5% On the treatment-regimen estimand, weight loss was 20.2% vs 23.6% Primary endpoint not met: CagriSema did not demonstrate non-inferiority vs tirzepatide on weight loss at 84 weeks Why this matters This is a reminder that in obesity pharmacotherapy, very effective and best-in-class are not the same conversation

Nat Neurosci 25(12):15841596 McDonald JW, Sadowsky C (2002) Spinal-cord injury

To date, only PSMA-targeted radiopharmaceuticals have received FDA approval, namely [ 68 Ga]Ga-PSMA-11, [ 18 F]DCFPyL (PYLARIFY ), and [ 177 Lu]Lu-PSMA-617 (Pluvicto )

Carter BZ, Kornblau S, Mak PY, Yang H, Qiu Y, Jiang X, Coombes K, Zhang N, Garcia-Manero G, and Andreeff M

Borgese, N., Aggujaro, D., Carrera, P., Pietrini, G