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The protective role of nutritional antioxidants - including glutathione precursors and direct glutathione supplementation - against impaired redox homeostasis in thyroid pathologies has been highlighted in a comprehensive review in PMC (2023), which confirmed that antioxidant interventions represent a promising adjunct strategy in the management of various thyroid conditions

These include cruciferous vegetables like broccoli, Brussels sprouts, and cauliflower, as well as allium vegetables like garlic and onions

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NRF2 is subsequently stabilized to transcriptionally upregulate antioxidant response genes including xCT, the rate-limiting enzyme in glutathione synthesis, glutamate cysteine ligase (GCL), and enzymes used in detoxification of ROS, such as GPx [42], to attenuate ROS damage